Promising natural products against nosocomial infections
Hafizur Rahman, Chowdhury Kamrul Hasan, Musfique Ahmed, Kazi Didarul Islam, M Ali Hossain
Globally, increasing drug resistance among nosocomial infections is a growing concern for medicine, which demands effective therapeutic regimes. Along with existing major scaffolds, namely penicillin, cephalosporin, quinolones, macrolides and tetracyclines, exploring new antibiotics with novel scaffold is a pressing necessity to combat multi-drug resistant pathogens causing hospital associated infections. Therefore, this review is intended to present the latest advances in the process of drug development from natural sources. The review shows that nature can provide a variety of scaffolds, though variability in the effectiveness exists among them. Consequently, an endeavour to isolate and characterize more potential antibiotics from nature is extremely important. In this aspect, the marine environment could be a promising source as it has been comparatively ignored to date.