Vol. 3, Issue 4 (2015)
The present study was undertaken to evaluate the therapeutic efficacy of Curcuma aromatica leaf extract in terms of normalization of altered electrolyte concentration following arsenic trioxide induced oxidative damage in rats. Arsenic is a metalloid widely distributed in the earth’s crust. Arsenic causes kidney damage at different doses by acute, subacute and chronic toxicity. Systemic electrolyte and water balance are controlled via kidneys, thus the serum electrolytes level provide vital information about the functional state of kidney. Electrolytes are ionized molecules found throughout the blood and tissues of body. Many studies have shown that various types of herbal plants have a wide range of biochemical and pharmacological effects due to their constituents. In this study, a herbal plant Curcuma aromatica was used which acts as a natural antioxidant. Arsenic trioxide generates hyponatremia, hypochloremia and hyperkalemia and reduction in body weight and kidney weight in albino rat. Which were brought to normalcy after treatment with Curcuma aromatica leaf extract containing curcumin after acute and sub acute treatment. Experimental results therefore reveal protective effect of Curcuma aromatica leaf extract under stressed condition of arsenic trioxide in albino rat.
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