European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 3, Issue 4 (2015)

Emerging resistance to meropenem in Pseudomonas aerugonisa Isolates among patients of a tertiary care hospital of Pakistan


Syed Bilal Tanvir, Kanaan Mansoor, Ali Shariq, Heba Shariq, Arif Hussain, Badar Jahan Farooqi, Roofia Tanvir

Background: To discern the prevalence of P.aerugonisa isolates from tracheal and bronchial aspirates and compare its emerging resistance pattern to meropenem with previous studies. Methods: A crossectional study was performed for a time frame of 2 years from January 2013 to January 2015 in 200 bedded tertiary care private hospital in Karachi. The isolates were cultured on chocolate and MacConkey agar. Meropenem sensitivity profile of P. aerugonisa isolates were deduced by utilizing Kirby Bauer Disc diffusion method on Meuller Hinton Agar. Results: A total of 634 isolates of P. aerugonisa from tracheal and bronchial aspirates during a study time frame of January 2013 to January 2015 were cultured. Positive cultures were most commonly observed in male samples who were above 50 years of age.66.1% of the isolates were sensitive to Meropenem while 33.9% of the isolates were resistant. Conclusions: P. aeruginosa isolates from samples of tracheal aspirate, Pus, Urine, Blood, Body fluids and Broncoalveolar lavage were collected and their prevalence was deduced. The increased resistance pattern of isolates to meropenem and its causes were also discerned.
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