Aim: To ascertain the prevalence and antimicrobial susceptibility and resistance pattern of Clindamycin in Methicillin resistant Staphylococcus aureus(MRSA) isolates of patients from a tertiary care hospital. Methods: A crossectional study was performed over a time period of 9 months and a total of 369 clinical specimens were obtained which included pus, wound swabs, ear swabs, eye swabs, urine, blood, tracheal aspirates and sputum samples. All specimens were processed using brain heart infusion broth. All other specimens (wound swabs, ear swabs, eye swabs, sputum, aspirates) were inoculated onto sheep blood, chocolate and MacConkey agar plates. Specimens were also inoculated on mannitol-salt agar and the incubation was extended to at least 48-72 hours for discernible colony development. SPSS version 20 was used to deduce the prevalence of MRSA and sensitivity to clindamycin. Results: Out of a total 369 strains of S.aureus 169 were found to be strains of MRSA which makes the prevalence at 44.71% for it. The age of patients ranged from 20-66 years. Out of the total male patients were 44% (n=163) while female patients were 56% (n=206).Majority of the lesions were found in pus 36.8 %( n=136) followed by tracheal aspirate 23.3 %( n=86). 100% MRSA isolates were resistant to Oxacillin and Cephalexin, 91.5% were resistant to Clindamycin and only 8.5% were sensitive to Clindamycin. All the isolates showed 100% sensitivity to vancomycin and linezolid.Conclusions: Our analysis of prevalence of MRSA in our hospital showed a regional high which is alarming. Therefore, a countrywide surveillance should be done to find the current prevalence across Pakistan. Secondly, awareness should be spread in the hospital as well as the community of this hidden vice.