Studies on the effects of the alkaloids of Cucumis metuliferus
fruit pulp on hepatitis B virusrnwas investigated in albino rats.
Materials and Methods: The alkaloids from C. metuliferus fruit pulp were isolated according to thernmethod described by Agrawal and Paridhavi  and the effect of the isolated alkaloids was assayed inrnalbino rats infected with hepatitis B serum.
Results: Results obtained showed that 50 – 200mg/kg of the alkaloids produced dosed – dependentrnstatistically significant (p<0.05) decrease in the levels of serum alkaline phosphatase (ALP), alaninernaminotransferase (ALT) and aspartate aminotransferase (AST) in albino rats infected with hepatitis Brnserum.
Conclusions: This result showed that alkaloid isolated from the fruit of C. metuliferus plant may havernsome protective activity against hepatitis B virus (HBV).