European Journal of Biotechnology and Bioscience

European Journal of Biotechnology and Bioscience

ISSN: 2321-9122

Vol. 3, Issue 7 (2015)

Alkaloids of Cucumis Metuliferus fruit pulp reduces hepatitis b virus (HBV) in laboratory animals

Author(s): A.A. Anyanwu, N.S. Jimam, D.A. Dangiwa, N.N. Wannang
Abstract: Objective: Studies on the effects of the alkaloids of Cucumis metuliferus fruit pulp on hepatitis B virusrnwas investigated in albino rats.
Materials and Methods: The alkaloids from C. metuliferus fruit pulp were isolated according to thernmethod described by Agrawal and Paridhavi [1] and the effect of the isolated alkaloids was assayed inrnalbino rats infected with hepatitis B serum.
Results: Results obtained showed that 50 – 200mg/kg of the alkaloids produced dosed – dependentrnstatistically significant (p<0.05) decrease in the levels of serum alkaline phosphatase (ALP), alaninernaminotransferase (ALT) and aspartate aminotransferase (AST) in albino rats infected with hepatitis Brnserum.
Conclusions: This result showed that alkaloid isolated from the fruit of C. metuliferus plant may havernsome protective activity against hepatitis B virus (HBV).
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