Preparation of silane functionalized mesoporous hollow silica nanospheres as drug carriers in photo dynamic therapy
Sultana Nayer, Khatoon Ayesha, Hossen Mubarak, Alam Md Khorshed
Photodynamic therapy (PDT) is a minimally invasive procedure where the photochemical reaction between light wave, photosensitizer (PS) and ground state oxygen produces toxic singlet oxygen（1O2. Selective accumulation of PS at the target site is one of the major requirements for effective PDT. Mesoporous silica nanoparticles (MSNPs) have exceptional physiochemical properties for application as nanocarriers in targeted PS delivery systems. In this study mesoporous hollow silica nanospheres (MHSNS) of uniform morphology, high surface area and dimensions about 100 nm were synthesized using the double template method. In order to facilitate covalent bonding with PS the surface of the synthesized MHSNSs were modified with 3-aminopropyl triethoxysilane (APTES) as the silane coupling agent. The functionalization process was optimized by varying different reaction conditions.