Though antibacterial resistance is not a recent phenomenon, it is a critical health issue today. Much of the antibacterial resistance problem stems from the misuse or excessive use of antibiotics. Effective antibiotic stewardship is required to ensure that antibiotics are prescribed and used responsibly.rnNDM-1 stands for New Delhi metallo-beta-lactamase enzyme. This enzyme destroys beta-lactam antibiotics including the penicillin’s, cephalosporins, and carbapenems. It is also found that NDM-1 can easily jump from one strain of bacteria to another, presenting major challenge for clinicians in treating the infections, often demanding use of combination antibiotics. To reduce the risk of incidence of NDM-1, physicians and hospitals should ensure that antibiotics are used judiciously and appropriately.