The basolateral amygdala (BLA) appears to be a potential brain area forrnregulating immune responses when its neuroanatomical connections and functionsrnare considered. The phagocytic activity of reticuloendothelial (RE) cells, a partrnof the innate immune responses, was used to assess the immunomodulatory effectsrnof different extracts from plants and animals. In an attempt to study thernimmunomodulatory role of BLA on the phagocytic activity of RE cells, BLA wasrnlesioned electrolytically in rats and the phagocytic activity of RE cells was assessedrnby carbon clearance test after two weeks of surgery along with the measurementrnof serum corticosterone level. The phagocytic activity of RE cells and serumrncorticosterone level were decreased in the BLA lesioned rats compared to thatrnof control and sham operated rats. This study shows that the phagocyticrnactivity of RE cells is suppressed in BLA lesioned rats which probably indicatesrna stimulatory influence of BLA on the observed innate immune response in intactrncontrol animals.