European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 5, Issue 1 (2017)
Antibiotic resistance is a major concern throughout world in all the microorganisms and especially in E.coli as it is a commensal bacteria and pathogenic variants are infectious. Presently it is important to design a systematic choice of antibiotics to avoid spread of multi drug resistance in E.coli. The aim of this study is to determine antibiotic susceptibility pattern of E.coli from different clinical samples in Kalaburagi region. About 150 isolates were isolated by standard methods and antibiotic susceptibility profiling was done.100% resistance to ampicillin and Nalidixic acid, 40% to amoxicillin/clavulinic acid, 80% to Cefotaxime, 70% to ceftazidime, 80% to ceforoxime, 81% to ciprofloxacin, 40% to levoflaxacin, 20% to gentamycin and 5% resistance to Imepenem was observed. Our study indicates that first three generation of beta-lactams antibiotic and fluroquinolones have limiting effect over MDR E. Coli. But most of strains were susceptible to Imepenem, gentamycin and to some extent amoxicillin clavulinic acid. MIC for cefotaxime and ceftaxime/clavulinic acid was performed to confirm the presence of ESBL enzymes in the resistance strains. Out of 150 strains 120 resistant strain were ESBL positive i.e., 60% strains. With proper data analysis this study can be used to decide an empirical antibiotic thearpy for E.coli infections.
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