Anti-leshmanial constituents from Corydalis govaniana Wall.
Ram Lal Shrestha, Achyut Adhikari
Four tetrahydro-protoberberine type alkaloid; govaniadine (1), caseadine (2), stylopine (3), and fagarine I (4) were isolated from Corydalis govaniana Wall. Their structure were deduced using different mass and NMR techniques. Compounds 1-4 were subjected to in vitro anti-leshmanial (L. major) activity. Compound 1 showed significant activity (IC 50 = 27.0± 0.2 µg/mL) against L. major.