European Journal of Biotechnology and Bioscience

European Journal of Biotechnology and Bioscience


European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 5, Issue 5 (2017)

Anti-leshmanial constituents from Corydalis govaniana Wall.


Ram Lal Shrestha, Achyut Adhikari

Four tetrahydro-protoberberine type alkaloid; govaniadine (1), caseadine (2), stylopine (3), and fagarine I (4) were isolated from Corydalis govaniana Wall. Their structure were deduced using different mass and NMR techniques. Compounds 1-4 were subjected to in vitro anti-leshmanial (L. major) activity. Compound 1 showed significant activity (IC 50 = 27.0± 0.2 µg/mL) against L. major.
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