Vol. 7, Issue 2 (2019)
Evaluation of preventive effects of Zinc, Vitamin D and their combination against Nephrotoxicity induced by Gentamicin in rats
Author(s): Serge D Kone, Goueh Gnahoue, Félix H Yapi
Abstract: The kidneys are key organs with important functions in regulating of the hydro-electrolyte equilibrium, in elimination of the waste products from the blood, and in maintaining of the organism’s acid-base balance. In acute renal failure, the kidney filtration capacity is altered, which results in an accumulation of the excessive amounts of wastes and also in a marked deterioration of renal structure with cell necrosis and apoptosis. Zinc (Zn) and Vitamin D (VD) are micronutrients implicated in many diseases. Our study was to evaluate the preventive effects of Zinc and Vitamin D in nephrotoxicity induced by gentamicin in rats. A total of seventy-eight albino rats were divided into thirteen groups of six male rats for each group according their body weight. Nephrotoxicity were induced by gentamicin injection after seven days treatment. The rats were treated respectively with 25 and 50 mg / kg of zinc and 6, 12 and 24 μg / kg of Vitamin D and also with combination of zinc and Vitamin D at the same concentrations. There was a significant increase in serum of Urea, Creatinine and Low Total Protein level in the serum of rats treated with Gentamicin compared to rats in the control lot. However, Zinc and Vitamin D supplementation caused a significant decrease in serum of Urea and Creatinine activity with elevation of Total Protein concentration in the serum of rats due to their combination. This study revealed that zinc (25 to 50 mg / kg) and Vitamin D (6; 12 and 24μg / kg) attenuate Gentamicin effect in rats. The best protective combination of kidney was 50 mg / kg Zinc combined with 12 and 24 μg / kg of Vitamin D (Zn 50 + 12 VD et Zn 50 + 24 VD). This study suggests that zinc combined with Vitamin D could be a good protective against nephrotoxicity induced by Gentamicin.