Vol. 7, Issue 2 (2019)
Hypobaric hypoxia (HH): Induced alterations of hematological responses in male rats are influenced by naproxen, vitamin C and vitamin E
Author(s): Ananda Raj Goswami, Tusharkanti Ghosh
Abstract: The physiological systems are affected in humans after exposure to simulated hypobaric hypoxia (HH). The aim of the present study was to investigate the changes of some hematological parameters during simulated hypobaric hypoxic (HHc) condition and to explore the role of prostaglandins (PGs) and/or oxidative stress on HH-induced hematological changes in male rats. The rats were exposed to HH at 18,000ft (380 Torr) in a simulated chamber for 8 h/day for 6 consecutive days. Different doses of naproxen (a non-steroidal anti-inflammatory drug), vitamin C and vitamin E were administered in separate groups of rats in both the HHc and normobaric conditions. The present study indicated that the TC of RBC, hemoglobin concentration and packed cell volume (PCV) were increased in HHc condition in rats. The HH-induced changes of the hematological parameters showed gradual recovery with graded doses of naproxen and vitamin E. But vitamin C at higher dose did not show any recovery of observed parameters indicating absence of anti-oxidant activity at the higher dose. The present study indicates that the observed hematological responses may be explained on the basis of the oxidative stress induced production of PGs and/or reactive oxygen species in HHc condition. The study also indicated the potential role of non-steroidal anti-inflammatory drug (naproxen), and antioxidants (vitamin C and E) on the maintenance of the homeostasis of the physiological impairments in high altitude.