Vol. 7, Issue 2 (2019)
The protectıve effect of shark cartilage (SC) and lıver oıl (SLO) against to colon and lung cancer by cell culture
Author(s): Elvan Akgül, Nadir Koçak, Tuğçe Duran, Vasfiye Betül Uçar, Mine Dosay Akbulut
Abstract: It is a fact that cancer disease is one of the biggest health problems today. It is important for cancer patients to maintain their immune system strong. Many research have been carried out to find better cancer treatments. The findings indicate that; the medicinal plants are widely used for the treatment of diseases as an complementary medicine. In treatment of this illness, additional to standard methods, sharks, with their cartilage and liver oil, has been presented as a one of these new sources in this study. Cell culture is a preferred method in terms of reducing the use of experimental animals, in that it can be done much more easily than many studies with experimental animals. With this study; it was aimed to determine the protective effect of SC (shark cartilage-dogfish cartilage) and SLO (shark liver oil-dog liver oil) as therapeutic agents against to colon cancer and lung cancer lines prepared by cell culture. For lung cancer; The H209 cells from the alum were cultured and "CaCo-2 / An1 (Human Colon Adenocarcinoma-human)" was used as a colon cancer line in our study. In comparison of SC and SLO effectiveness against to lung and colon cancer lines; SC application was more effective showing its killing cancer cells effect in shorter time with lower doses compare to SLO application in colon cancer lines; the SLO was a little more effective, showing its killing effect in lower doses with the same period of time; compare to SC application in lung cancer lines.