The objective of study was exploitation of genetic interaction, and variability shown by yield contributing and ionic concentration traits for development of salt tolerance genotypes. Thus, genetic variation was created by hybridizing six tolerant and three susceptible genotypes. Thus, 27 genotypes were tested at salinity level of NaCl@ 20dSm-1 long with control (normal soil). Moderate to high variability by PCV and GCV values indicated the possibility to get salt tolerant genotypes. High broad-sense heritability and increased variability suggested that yield contributing traits were strictly under genetic control. High heritability with moderate to high genetic advance for yield contributing traits suggested selection may result in considerable improvement under salinity stress. Additive gene action was exhibited by plant height, number of bolls plant-1, Na+, K+ and K+/Na+ ratio. While, mixed trend of additive and non-additive gene action was observed for boll weight and seed-cotton yield plant-1. Total variance indicated that salt tolerance in NIAB-999, CIM-707, NIAB-78, MNH-93, CIM-446, CIM-443 was due to high uptake of K+ and thus maintaining a highest K+/Na+ ratio in their leaves. This highest uptake of K+ and balancing ratio of K+/Na+ ratio may lead to increased seed-cotton yield plant-1. The derived information could be helpful to design breeding scheme against salt stress.