Beneficial effect of Elaeocarpus ganitrus in Haloperidol induced parkinsonian disease in animal model
Rohini Kallur, Krisma Raj
Background: Elaeocarpus ganitrus (Family: Elaeocarpaceae), has been used for the treatment of depression, convulsions and asthma. The existing literature is lacking in studies showing antiparkinson effect of E.ganitrus. There is increased concern about the side effects of conventional medicine in the treatment of Parkinson’s disease (PD), hence E.ganitrus having antioxidative property may be a safer alternative. Materials & Methods: To evaluate the antiparkinson effect of E.ganitrus, rota rod and catalepsy bar tests were used. Assessment of oxidative stress was done by measuring the malondialdehyde (MDA) and reduced glutathione (GSH) levels in the striatal region of the brain. One way ANOVA was used to detect statistical significance followed by post-hoc Tukey test. Results: E.ganitrus (200 and 400 mg/kg, p.o.) pretreated groups significantly increased the retention time in rota rod test (p <0.001) and significantly decreased the latency period in catalepsy bar test (p <0.001), when compared to Haloperidol treated group alone. E.ganitrus (200 and 400 mg/kg, p.o.) pretreated groups showed significant anti- oxidative effect by causing a decrease in brain MDA levels (p <0.001) and a significant increase in GSH levels (p <0.001). Conclusions: Oxidative stress plays vital role in pathophysiology of Parkinson’s disease. The results of the present study conclusively show that E.ganitrus has antioxidant activity and neuroprotective activity in Haloperidol experimental model of Parkinson’s disease.