European Journal of Biotechnology and Bioscience

European Journal of Biotechnology and Bioscience


European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 7, Issue 5 (2019)

Haematological studies on the effect of antioxidants vitamin C, E and garlic on tramadol-induced toxicity in wistar rats


Ukpanukpong RU, Eban LK, Eteng MU, FD Adebiyi, Yusuff AA, Aigbadumah PO, Ekeke PO

The effect of antioxidants, vitamin C, E and garlic on tramadol-induced toxicity was studied in wistar rats. Thirty five (35) rats were used and designated into five (5) study groups with seven (7) rats each. There was a significant decrease in the body weight of the negative control group when compared with the positive control group. However, there was a significant increase in the body weight of the experimental groups administered antioxidants, vitamins C, E and garlic when compared to the negative control group at (P<0.05). The weight of the liver in the negative control group increases significantly when compared to the weight of the liver in the positive control group. This shows the metabolic changes in the liver as it metabolizes the drug which results in inflammation of the liver. The weights of the heart and kidney also showed similar variations in the graphs. The RBC’s, Hb, PCV, MCV, MCH and MCHC levels were all decreased in the negative control group when compared to the positive control group. This is largely due to the effect of drug on erythropoiesis and nutritional deficiencies caused by lack of appetite. There was a significant increase in RBC’s Hb, PCV, MCV, MCH and MCHC levels in the experimental groups administered antioxidants, vitamin C, E and garlic when compared with the negative control group at (P<0.05). The WBC’s level was increased in the negative control group when compared to the positive control group. This is due to the activation of defense mechanism and immune system of the wistar rats. There was a significant increase in the WBC’s Level In The Experimental Groups Administered Antioxidants, Vitamin C, E And Garlic When compared to the negative control group at (P<0.05).
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