Review on nomenclature and classification of lipoxygenase and its medical applications
R Indhu sri, A Afrin2, A Gowsalya, M Neevika, S Chozhavendhan, N Prabhu
Lipoxygenase (LOX) are dioxygenase that catalyze the formation of corresponding hydro peroxide from polyunsaturated fatty acid (PUFA) such as linoleic acid and arachidonic acid. However, in order to study and optimize its application in industrialized settings pure LOX isozymes are required. Such kind of enzyme also present in plants, animals, fruits and vegetables. Soyabean seeds are the richest known source of lipoxygenase, contributing up to 2% total protein content. The present study showed that the 3 lipoxygenase isozymes isolated from defatted soybean flour exhibited inhibition potential by modulating the enzyme to substrate ratio.The LOX enzymes is classified into plant lipoxygenase, human lipoxygenase and mouse lipoxygenase. The LOX enzymes is majorly found in soyabean seed. It took Biotechnological applications such as in baking and later flavor production. The LOX has an enormous functions and pathophysiological conditions, Alzheimer’s disease and neuropathic pain and etc.., but it required in pure form. The nomenclature and classification of LOX was described in this article.