European Journal of Biotechnology and Bioscience


Biotechnology and Bioscience



Vol 2, Issue 6, 2014

Anti-angiogenesis property by Quercetin compound targeting VEGFR2 elucidated in a computational approach

Author(s): Syed Hussain Basha, Prakash Bethapudi, Majji Rambabu, Firoz. A, N.V.S. Viswanadha murty M, Sreenivasa reddy E

Abstract: Quercetin is a naturally occurring flavonoid compound found in various species of vegetables and fruits. This compound have been widely demonstrated for having various medicinal properties including its capacity to inhibit enzymes that activate carcinogens, anti-viral, antioxidative activity as well as to modify signal transduction pathways by interacting with regulatory cell receptors etc., On the other hand, recent reports have evidenced significant anti-angiogenesis property of this compound on rat models targeting VEGFR2 regulated signalling pathways. In this scenario, we have carried out this present study to elucidate the underlying interactions responsible for this strong target specific inhibition at the molecular level using different computational approaches. Our docking, binding free energy along with molecular dynamic simulation studies revealed various interactions responsible for this target specific binding involving large negative binding energies. Quercetin compound demonstrated out ruling properties and interactions when compared the results with the VEGFR2 co-crystallized ligand AAZ. The present results would be of high value for further designing potent target specific anti-angiogenesis drug compounds.

Download Full Article : Click Here




Indexing Information

Abstracting & Indexing

The journal is indexed with Dahlgren Memorial Library, Georgetown University Library, Max Perutz Library, University Library of Regensburg, The Hamburg State and University Library, Library of Clausthal University of Technology, Geneva Foundation for Medical Education and Research and many more.


Subjects Covered

  • The Journal provides a medium for the rapid publication of both full-length articles and short communications on novel and innovative aspects of Biotechnology, Genomics and Bioinformatics, Molecular Biology, Biochemistry, Biochemical Engineering, Bioprocess Engineering, Industrial Processes, Medical Biotechnology, Agro and Food Biotechnology.

Advertise With Us

Biotechnology Journal has open access policy thus ensure good visibility of the online content of the journal. The journal have high circulation and visibility online, thus offer excellent media for promotion of your products, services or conferences through advertisement. If you have further queries, we would be happy to answer those. Please contact us at