Protective Effect of Nigella Sativa Oil and Seasame Oil on Hypercholesterolemia and Diabetes Induced Metabolic Alterations
M. Kamal E. Youssef, Randa S. Hana, Nareman S. Eshak
Aim: Investigate the effect of nigella sativa and sesame oil on several risk parameters for diabetes and hypercholesterolemia. For 3 weeks: a) 2 groups, 10 rats/group were given either nigella sativa or sesame oil (1 ml/kg) and compared to 10 control rat. B) 2 groups, 10 rat/group were given these oils with induction of diabetes by streptozotocin (50 mg/kg) and compared to 10 streptozotocin induced diabetic rat. c) 2 groups,10 rat/group were given these oils with induction of hypercholesterolemia (10% cholesterol enriched diet) and compared to 10 hypercholesterolemic rats to evaluate these oils effect on hepatorenal function, leptin ,insulin , glucose ,antioxidants, malondialdhyde and lipid profile. Results: Oils intervention increased the unsaturated fatty acids and antioxidants. Induction of diabetes and hypercholesterolemia produced oxidative stress, hyperlipidaemia that was improved with sesame oil and less with n.sativa oil .Serum glucose, insulin and leptin increased in hypercholesterolemic rats and significantly decreased after oils intervention. Furthermore, n.sativa - and less sesame oil - decreased serum glucose and partially restored serum insulin and leptin in diabetic group. Conclusion: N.sativa oil possess a better improving potential for diabetes and sesame oil possess a better improving potential for hypercholesterolemia.