Emerging prognostic biomarkers for laryngeal squamous cell carcinoma in Egyptian population
Randa S. Hana, Bahaa L. Bawi
Laryngeal cancer is a common respiratory cancer; GST polymorphisms have been associated with solid tumors. VEGF, sialic acid and P53 are important prognostic markers of cancer. Aim: To determine the significance of the GSTM1 and GSTT1null genotypes, VEGF, sialic acid and P53 in 69 patients with laryngeal cancer compared to 69controls. Methods: GSTM1 and GSTT1 genotype, VEGF, P35 and sialic acid were tested by PCR, ELISA and by chemical methods respectively in 69 patients compared to 69 controls in relation to patient characteristics, survival and response to therapy Results: GSTM1 and GSTT1 null genotypes were detected in 39.1%, 52.1% of controls and 56.5%, 73.9% of patients respectively associated with high level of VEGF, sialic acid, P53, advanced staging, poor survival and response to treatment. The double-null genotypes predicted worse prognosis. Conclusion: GSTM1, GSTT1 null genotypes, high VEGF, sialic acid and P53 comprise valuable diagnostic and prognostic tests of laryngeal cancer. This is the first study that examined GST polymorphisms in cancer larynx in Egypt. Replication of these findings in larger population is warranted.
Randa S. Hana, Bahaa L. Bawi . Emerging prognostic biomarkers for laryngeal squamous cell carcinoma in Egyptian population. European Journal of Biotechnology and Bioscience, Volume 2, Issue 1, 2014, Pages 39-48