European Journal of Biotechnology and Bioscience

European Journal of Biotechnology and Bioscience


European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 3, Issue 10 (2015)

Mechanism of action of human papilloma virus in cancer


IPamela Banerjee, Rajarshi Kayal

Human papillomaviruses (HPVs) are associated with human cancer. HPVs cause various epithelial lesions due to their infection.rnCell differentiation process of infected host cell is closely related to the viral life cycle of HPV. Immune system plays a vital role torncontrol HPV infections. HPVs genomes encode eight translation open reading frames (ORFs) depending on splicing and sites ofrntranscriptional initiation. HPV 16, a high risk human pappiloma virus (HR-HPVs), is associated with the vast majority of HPVrnpositive HNSCC. HPV 16 E7 acts as the dominant viral oncogene in cervical, anal and head & neck carcinogenesis. Pocket ProteinrnSupress Head and neck Cancer. p21Cip1 functions as a tumor suppressor in cervical carcinogenesis and inactivation of p21Cip1 byrnHPV-16 E7 partially account for the contribution of HPV-16 E7 to cervical carcinogenesis.
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How to cite this article:
IPamela Banerjee, Rajarshi Kayal. Mechanism of action of human papilloma virus in cancer. European Journal of Biotechnology and Bioscience, Volume 3, Issue 10, 2015, Pages 26-30
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