European Journal of Biotechnology and Bioscience

Authors
IPamela Banerjee, Rajarshi Kayal

Abstract
Human papillomaviruses (HPVs) are associated with human cancer. HPVs cause various epithelial lesions due to their infection.rnCell differentiation process of infected host cell is closely related to the viral life cycle of HPV. Immune system plays a vital role torncontrol HPV infections. HPVs genomes encode eight translation open reading frames (ORFs) depending on splicing and sites ofrntranscriptional initiation. HPV 16, a high risk human pappiloma virus (HR-HPVs), is associated with the vast majority of HPVrnpositive HNSCC. HPV 16 E7 acts as the dominant viral oncogene in cervical, anal and head & neck carcinogenesis. Pocket ProteinrnSupress Head and neck Cancer. p21Cip1 functions as a tumor suppressor in cervical carcinogenesis and inactivation of p21Cip1 byrnHPV-16 E7 partially account for the contribution of HPV-16 E7 to cervical carcinogenesis.