A review-potential angiogenesis targets and frontiers in cancer research: anthrax toxin’s receptors
The role of cognate host receptors of anthrax toxin binding protein, Tumor Endothelial Marker-8 (TEM-8) and CapillaryrnMorphogenesis Gene-2 (CMG-2) are being delineated from entry portals of anthrax toxin proteins to intercellular site to beingrnregulators in angiogenesis. In vitro and in vivo model systems had documented their upregulation on endothelial cells undergoingrnangiogenesis or blood vessel growth. Inhibiting angiogenesis (formation of new blood vessels), which are feeding and supportingrntumors are also one of the current targets of anti-cancer therapies. TEM-8 and CMG-2 are highly upregulated during angiogenesisrnand bind differentially to extracellular matrix proteins including collagen I, collagen VI, collage XIV and laminin. TEM-8 and CMG-rn2 regulate endothelial cell migration, proliferation and tubule formation which make them apparently good targets as anti-angiogenicrnand anti-tumorigenic therapeutics. This intriguing finding has also led to detailed studies on the strategies of designing modifiedrnforms of anthrax toxin proteins (Protective Antigen, Lethal Factor, Edema Factor) which impairs the normal cellular activities torncombat tumor endothelium specifically.
Sugandha Bhatia. A review-potential angiogenesis targets and frontiers in cancer research: anthrax toxin’s receptors. European Journal of Biotechnology and Bioscience, Volume 3, Issue 10, 2015, Pages 45-51