Susceptibility Pattern of Trimethoprim/ Sulfamethoxazole in Methicillin Resistant Staphylococcus aureus Isolates of a Tertiary Care Hospital in Karachi

Arfa Masihuddin; Mehak Fatima; Syed Bilal Tanvir; Zahra Rehman; Ali Shariq; Arif Hussain

Susceptibility Pattern of Trimethoprim/ Sulfamethoxazole in Methicillin Resistant Staphylococcus aureus Isolates of a Tertiary Care Hospital in Karachi

Authors
Arfa Masihuddin, Mehak Fatima, Syed Bilal Tanvir, Zahra Rehman, Ali Shariq, Arif Hussain

Abstract
Objective: To comprehend the frequency, resistance and susceptibility pattern of MRSA isolates tornTrimethoprinin/Sulfamethoxazole in a tertiary care hospital in Karachi.

Methods: A prospective cross-sectional study was performed and a total of 369 clinical specimens, which comprised of eye, ear,rnwound and pus swabs, blood, urine, sputum samples and tracheal aspirates which were cultured for time frame of 1 year. Standardrnand specific microbiological techniques were used to identify positive cultures. Out of a total of 369 isolates 165 were found to bernMRSA. Spss version 22 was used for statistical analysis.

Results: In study it was deduced that 82.4% of the MRSA strains were resistant to Trimethoprim/Sulfamethoxazole as compared tornClindamycin to which 91.4% of the strains were resistant, while all strains of MRSA were 100% susceptible to Vancomycin.rnA slightly higher resistance (83%) to Trimethoprim/Sulfamethoxazole of MRSA strains in age group 31-40yrs was noted whenrncompared with other age groups. While resistance to Clindamycin was also slightly increased in age group 20-30yrs.

Conclusions: Trimethoprim/Sulfamethoxazole has maintained its susceptibility to MRSA when compared with Clindamycin butrnremained inferior to Vancomycin based on data gathered from the antibiogram. Trimethoprim-Sulfamethoxazole can still bernconsidered as a suitable option for treatment of nosocomial MRSA infections in selected cases as an alternative to Clindamycin andrnVancomycin.

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