Susceptibility Pattern of Trimethoprim/ Sulfamethoxazole in Methicillin Resistant Staphylococcus aureus Isolates of a Tertiary Care Hospital in Karachi
Arfa Masihuddin, Mehak Fatima, Syed Bilal Tanvir, Zahra Rehman, Ali Shariq, Arif Hussain
Objective: To comprehend the frequency, resistance and susceptibility pattern of MRSA isolates tornTrimethoprinin/Sulfamethoxazole in a tertiary care hospital in Karachi.
Methods: A prospective cross-sectional study was performed and a total of 369 clinical specimens, which comprised of eye, ear,rnwound and pus swabs, blood, urine, sputum samples and tracheal aspirates which were cultured for time frame of 1 year. Standardrnand specific microbiological techniques were used to identify positive cultures. Out of a total of 369 isolates 165 were found to bernMRSA. Spss version 22 was used for statistical analysis.
Results: In study it was deduced that 82.4% of the MRSA strains were resistant to Trimethoprim/Sulfamethoxazole as compared tornClindamycin to which 91.4% of the strains were resistant, while all strains of MRSA were 100% susceptible to Vancomycin.rnA slightly higher resistance (83%) to Trimethoprim/Sulfamethoxazole of MRSA strains in age group 31-40yrs was noted whenrncompared with other age groups. While resistance to Clindamycin was also slightly increased in age group 20-30yrs.
Conclusions: Trimethoprim/Sulfamethoxazole has maintained its susceptibility to MRSA when compared with Clindamycin butrnremained inferior to Vancomycin based on data gathered from the antibiogram. Trimethoprim-Sulfamethoxazole can still bernconsidered as a suitable option for treatment of nosocomial MRSA infections in selected cases as an alternative to Clindamycin andrnVancomycin.
Arfa Masihuddin, Mehak Fatima, Syed Bilal Tanvir, Zahra Rehman, Ali Shariq, Arif Hussain. Susceptibility Pattern of Trimethoprim/ Sulfamethoxazole in Methicillin Resistant Staphylococcus aureus Isolates of a Tertiary Care Hospital in Karachi. European Journal of Biotechnology and Bioscience, Volume 3, Issue 10, 2015, Pages 11-13