Prevalence of Salmonella typhi and Paratyphi in urine cultures and their antibiotic sensitivity patterns in karachi
Farhan Essa Abdullah, Syed Bilal Tanvir, Ali Zain Syed, Muhammed Fawwaz Haq, Ali Shariq, Sumaira Ahmed
Background: To ascertain the prevalence of Salmonella typhi and S. paratyphi serotypes in urine, their role in causing urinary tract infection and their antibiotic sensitivity patterns. Methods: A retrospective study was conducted on isolates grown on CLED, Chocolate agar and EMB medium from routine patient urine specimens over a period of six months from Jan-July 2012 in a private clinical lab in Karachi. Pertinent antibiotic susceptibility profiles of the Salmonella isolates were established using Kirby Bauer disc diffusion method on Mueller Hinton agar. Results: A total of 41 specimens yielded three serotypes of enteric fever Salmonellae among 2252 samples of urine (1.82%) cultured during the study period from Jan-July 2012.This finding was more commonly seen in female samples, especially those of elderly women. Approximately 80.4% of these individuals had significant bacteriuria with viable counts of 104/ml urine or greater. Cefixime, cefotaxime and ceftriaxone exerted satisfactory antibiotic effect while significant resistance was seen to the fluoroquinolones ciprofloxacin (24.4%) and ofloxacin (21.6%), and cotrimoxazole (38.5%). Conclusions: Salmonellae in urine and their possible role in causing urinary tract infection were assessed. The preferred empirical choice of drugs for treating salmonella UTI was ascertained.
Farhan Essa Abdullah, Syed Bilal Tanvir, Ali Zain Syed, Muhammed Fawwaz Haq, Ali Shariq, Sumaira Ahmed. Prevalence of Salmonella typhi and Paratyphi in urine cultures and their antibiotic sensitivity patterns in karachi. European Journal of Biotechnology and Bioscience, Volume 3, Issue 3, 2015, Pages 35-38