European Journal of Biotechnology and Bioscience

European Journal of Biotechnology and Bioscience


European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 3, Issue 5 (2015)

Antimicrobial effect and phytochemical analysis of Aframomum melegueta on some selected bacteria and fungi


Odetunde, S. K, Adekola, I.T, Avungbeto, M.O, Lawal, A. K

Antibiotic toxicity and multidrug resistant pathogens are the two greatest challenges being faced by today’s medical world. In this present study, the antimicrobial activity of spices has been investigated as an alternative to antibiotics in order to tackle these dangers. The choices of spice as an alternative is based on two basic reasons: firstly, plants have been the model sources of medicine since ancient times and secondly the increasing acceptance of herbal medicines by general population as therapeutic against many pathological infection. In this present study, the antimicrobial activity of alligator pepper leave has been investigated against local clinical bacterial and fungal isolates. The methanol extract has been assayed separately against drug resistance, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus sp., Salmonella sp., Bacillus sp., Escherichia coli, Klebsiella sp., Saccharomyces sp., Aspergillus and Candida.The antibacterial and antifungal activities were determined by disc diffusion method. The result shows that the zone of inhibition of methanol extract for 48hours was more effective compare to that of 24hours of which klebsiella sp. has the highest zone of inhibition for the methanol extract. The water extract at 48hours was discovered to possess a higher inhibition zone on Staphylococccus aureus, Pseudomonas sp., Proteus sp., Salmonella sp., Baccillus sp., Klebsiella sp., Aspergillus sp., Candida sp. and Saccharomyces sp. with the following inhibition zone respectively: 40mm, 40mm, 45mm, 45mm, 45mm, 50mm, 45mm, 45mm and 40mm. Escherichia coli has the lowest inhibition zone both the methanol extract and water extract with the inhibition zone of 25mm after 24hours and 35mm after 48hours for water extract while the methanol extract has the inhibition zone of 40mm for 24hours and 55mm for 48hours. In the light of several socioeconomic factors of Nigeria mainly poverty and poor hygienic condition, present study encourages the use of spice (alligator pepper seed) as supplementary medicine to reduce the burden of high cost, side effects and progressively increasing drug resistance of pathogen.
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How to cite this article:
Odetunde, S. K, Adekola, I.T, Avungbeto, M.O, Lawal, A. K. Antimicrobial effect and phytochemical analysis of Aframomum melegueta on some selected bacteria and fungi. European Journal of Biotechnology and Bioscience, Volume 3, Issue 5, 2015, Pages 15-19
European Journal of Biotechnology and Bioscience