European Journal of Biotechnology and Bioscience

Authors
Ravish Kumar Chauhan

Abstract
Salicyclic acid has been suggested to be the simplest model for substances in natural waters(1) and a convenient ligand substrate for biologically relevant tyrosine phenoxide and glutamic /aspartic carboxylate functions(2). It can adopt several bonding modes(3) and act as an effective agent for the synthesis of photoactive carboxylato polynuclear manganese complexes(4). Salicylates of different metal ions(5) have wide spread applications both as antiseptic and medicinal agents(6).The mononegative hydrazone ligands coordinate to the metal atoms through azomethine nitrogen, carbonyl oxygen and sulphur of thiophene ring (HL1)/ nitrogen of pyridine ring(HL2) and found to have square pyramidal geometry around each vanadium ion. Ligands and complexes were screened for in vitro antibacterial activity and antifungal activity at different concentrations against bacteria viz. Gram positive Bacillus subtilis, Micrococcus Luteus and Gram negative Pseudomonas aeruginosa, Pseudomonas mendocina and fungi Verticillum, Cladosporium, Tinospora. A distinct enrichment in biocidal active