European Journal of Biotechnology and Bioscience

Authors
Oluwatosin K. Shittu, Bashir Lawal, Garba M. Haruna, Eustace B. Berinyuy, Abubakar A. Yusuf, Aisha M. Ibrahim

Abstract
The hepatoprotective effects of methanol extracts from bee propolis against carbon tetrachloride (CCl4)rninduced liver damage in albino rats were evaluated. Twenty rats of wister strains were group into 4 (A-D)rnof 5 rats each: Group A and B serves as normal control and CCL4 control respectively while group C andrnD were treated with 600mg/kg methanol extracts of bee propolis and 100mg/kg Silymarin (Standard)rnrespectively. The CCL4 were administered in 72hrs interval intraperitoneally, while the extract was givenrndaily for 10days through oral route. The ALT activities in serum and liver were significantly (p<0.05)rnhighest and Lowest respectively in negative control rats when compared with normal control and otherrnexperimental groups, however rat treated with propolis extract compared well (p>0.05) with controlrnvalue in their serum and liver ALT activites. The serum AST activities were significantly (p<0.05) raisedrnin negative control rats when compared with normal control and other experimental group. However, nornsignificant (p>0.05) difference were observed in Liver AST activities of all experimental groups whenrncompared with the control values. The ALP activities in serum and liver were significantly (p<0.05)rnlowest and highest respectively in negative control rats when compared with normal control and otherrnexperimental group. The liver ALP of rats treated with sylimarin and propolis compared well with therncontrol value.The serum and Liver Total proteins were significantly (p<0.05) highest in the control ratsrnthan all other experimental group. The serum and Liver Total proteins in propolis treated rats comparedrnwell (P>0.05) with the negative control rats and were significantly higher than the sylimarin treated rats.rnIn conclusion, bee propolis has ameliorated the adverse effects of CCL4 induced Liver damage and couldrntherefore, be recommended as an effective natural product for the management of liver disease