Alkaloids of Cucumis Metuliferus fruit pulp reduces hepatitis b virus (HBV) in laboratory animals

A.A. Anyanwu; N.S. Jimam; D.A. Dangiwa; N.N. Wannang

Alkaloids of Cucumis Metuliferus fruit pulp reduces hepatitis b virus (HBV) in laboratory animals

Authors
A.A. Anyanwu, N.S. Jimam, D.A. Dangiwa, N.N. Wannang

Abstract
Objective: Studies on the effects of the alkaloids of Cucumis metuliferus fruit pulp on hepatitis B virusrnwas investigated in albino rats.

Materials and Methods: The alkaloids from C. metuliferus fruit pulp were isolated according to thernmethod described by Agrawal and Paridhavi ^[1] and the effect of the isolated alkaloids was assayed inrnalbino rats infected with hepatitis B serum.

Results: Results obtained showed that 50 – 200mg/kg of the alkaloids produced dosed – dependentrnstatistically significant (p<0.05) decrease in the levels of serum alkaline phosphatase (ALP), alaninernaminotransferase (ALT) and aspartate aminotransferase (AST) in albino rats infected with hepatitis Brnserum.

Conclusions: This result showed that alkaloid isolated from the fruit of C. metuliferus plant may havernsome protective activity against hepatitis B virus (HBV).

Download | Pages : 05-07