Alteration in salivary parameters lead to oral lesions among chewable tobacco users
Areeba Qamar, Saeeda Baig, Asghar Ali, Muhammad Asif Memon
Background: Salivary flow and composition alters under deleterious chemical irritants present in chewable tobacco. Apart from inflammation and deterioration in health of oral mucosa it can also affect the major and minor salivary glands and cause a decline in salivary flow rate. The objective of the study was to find out alteration in salivary parameters that lead to oral lesions among chewable tobacco users
Methods: A total of 354 healthy male subjects, consuming any form of chewable tobacco product, belonging to low socioeconomic areas of Karachi were selected for this cross sectional study. A questionnaire was used to collect demographic data and details of chewing habits (using since, pack/day, duration of exposure etc.). Resting saliva of every subject was collected for 5min and Resting Salivary Flow Rate (RSFR) was expressed in ml/min. Salivary pH was determined by using pH strips (pH 0-14). Oral examination was done for the presence or absence of oral lesions. Data was analyzed on SPSS version 20.
Results: Out of the 354 subjects included, 27.4% consumed gutka, 24.3% niswar, 24.3% paan and 24% were multiple users. Mean RSFR was 0.52±0.34 ml/min and pH 6.58±0.78. Among these 96 (27.1%) had oral lesions with highest frequency observed among subjects who had hyposalivation (40%) and those having acidic pH (40%). A significant decrease in RSFR and pH and increase in frequency of oral lesions is observed with increased duration of exposure, duration of usage and increased number of tobacco packs consumed per day.
Conclusion: Consumption of chewable tobacco leads to decrease in RSFR and pH and hence increase in frequency of oral lesions
Areeba Qamar, Saeeda Baig, Asghar Ali, Muhammad Asif Memon. Alteration in salivary parameters lead to oral lesions among chewable tobacco users. European Journal of Biotechnology and Bioscience, Volume 4, Issue 1, 2016, Pages 56-62