European Journal of Biotechnology and Bioscience

Authors
Idakwoji Precious Adejoh, Okafor Stephen Chiadikaobi, Akuba Ojochegbe Barnabas, Ajayi Oluwakemi Ifeoluwa, Hassan Shehu Muhammed

Abstract
This study comparatively evaluated the in vivo and in vitro antidiabetic potentials of ethanol extracts of Moringa oleifera seed, stem, flowers, leaves and roots. In the in vivo study, diabetes was induced in rats by intraperitoneal injection of 150 mg alloxan/ kg body weight. Graded doses (100, 200, 400 and 800 mg/ kg) of each extract were administered to different sets of diabetic rats and their blood glucose levels monitored at 1, 2, 3, and 6 hr post- treatment. The percentage glycaemic reduction at each hour by each dose level was calculated. In the in vitro studies, different concentrations of each extract were subjected to α-amylase and α-glucosidase inhibitory assays and the percentage inhibition produced estimated. Results showed that the seed followed by the leaves extracts produced more glucose lowering/ enzyme inhibition activities. It was concluded that the leaves and seed of M. oleifera possess more anti-diabetic activity than its root, stem and flowers.