European Journal of Biotechnology and Bioscience

European Journal of Biotechnology and Bioscience


European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 4, Issue 11 (2016)

Acute toxicity and indirect effects on the NA+/K+ ATPase pump of chloroform extract of Mansonia altissima (Sterculiaceae) in rabbits


Mansour Franck Adeoti, Philippe Bidie, Massara Camara-Cisse, Gnate Francois Onteomo, Kouamé Innocent Kolia, Konan Gogahy, Allico Joseph Djaman, Mireille Dosso

Mansonia altissima bark is known as poison but also for these multiple effects including cardio- protective effect. This study determine to acute toxicity and effect on the Na+/K+ of chloroform extract of Mansonia altissima bark. Acute toxicity of chloroform extract of Mansonia altissima was conducted. Then, ion pool was performed by administrating increasing doses (4.7-75 mg/kg) of chloroform extract in 36 rabbits devised in 7 lots and ion (Ca2+, Mg2+, Na+ and K+) were determinate by spectrophotometer analyzer. The results showed a lethal lose 100 (DL100) of 125 mg/Kg, lethal lose 50 (LD50) of 92.5 mg/Kg and maximum tolerated dose (MTD) of 75 mg/Kg in mice type albino. The value of LD50 indicates that chloroform extract has moderate toxicity. Results of ion pool showed significant (p<0.05) decrease of Na+ and non-significant Ca2+ concentrations in plasma, associated with non-significant first increase (p<0.01) in plasma of K+ concentration for lower doses of extract at 18.7 mg/kg of body mass weight. Plasma concentrations of Mg2+ were also experienced a non-significant increase (p <0.10) in relation to the pump Na+/K+ ATPase inactivation. These results relate that administration of non-toxic doses of chloroform extract of Mansonia altissima bark inhibit action on Na+/K+ ATPase and myocardial contraction.
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How to cite this article:
Mansour Franck Adeoti, Philippe Bidie, Massara Camara-Cisse, Gnate Francois Onteomo, Kouamé Innocent Kolia, Konan Gogahy, Allico Joseph Djaman, Mireille Dosso. Acute toxicity and indirect effects on the NA+/K+ ATPase pump of chloroform extract of Mansonia altissima (Sterculiaceae) in rabbits. European Journal of Biotechnology and Bioscience, Volume 4, Issue 11, 2016, Pages 29-33
European Journal of Biotechnology and Bioscience European Journal of Biotechnology and Bioscience