European Journal of Biotechnology and Bioscience

European Journal of Biotechnology and Bioscience


European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 4, Issue 3 (2016)

Nano drug delivery systems in photo dynamic therapy


Sultana Nayer

Photodynamic therapy is an alternative therapeutic procedure for the treatment of cancerous and neurological diseases. It is a minimally invasive procedure where the photochemical reaction between light wave, photosensitizer (PS) and ground state oxygen produces toxic singlet oxygen (1O2). The highly reactive singlet oxygen destroys target cells by direct cellular damage, vasculature shutdown and an immune response against the target cell. The effectiveness of PDT depends on the 1O2 generation capacity of the PS, accumulation of the PS and availability of ground state oxygen at the target site. A model PS for PDT should be a nontoxic pure compound of known composition with high singlet oxygen generation capacity. Accumulation of PS at the diseased cells at therapeutic concentration is essential for effective PDT. A vast range of potential PS exists with high singlet oxygen quantum yield but very poor accumulation at the target site. These limitations can be eliminated by conjugating the PS to a nanocarrier system for more efficient drug delivery at the target site. The unique physiochemical properties of diverse nanoparticles make it a versatile platform for developing targeted drug delivery systems. PS conjugation to nanocarrier systems can greatly improve its bio distribution and pharmacokinetics.
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How to cite this article:
Sultana Nayer. Nano drug delivery systems in photo dynamic therapy. European Journal of Biotechnology and Bioscience, Volume 4, Issue 3, 2016, Pages 06-11
European Journal of Biotechnology and Bioscience