European Journal of Biotechnology and Bioscience

European Journal of Biotechnology and Bioscience


European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 4, Issue 3 (2016)

Monocrotophos (An organophosphate) induced changes in Phospholipids in the Liver of female albino rat: Histochemical Studies


Dr. Kavita Arora

Six groups of female albino rats were taken for experimental work. 1/5th of LD50 dose (14 mg/kg body weight) of monocrotophos was administered by intragastric intubation to groups TI, TII and R for 15 days, 30 days, and 30 days with recovery of 15 days respectively. Corresponding controls for all the three groups were fed on normal diet. For histochemical studies, liver was collected from various groups at the end of the experiment and the techniques for the fixation of lipids and the preparation of slides were used. In control group rats, the liver tissue revealed blue stained small granules and large phospholipids bodies, whereas decrease in phospholipid granules in TI and TII groups was observed. The group R showed moderate recovery in the level of phospholipid studied histochemically. Thus it appears that this pesticide interferes with phospholipids metabolism through oxidative stress resulting in hepatotoxicity.
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How to cite this article:
Dr. Kavita Arora. Monocrotophos (An organophosphate) induced changes in Phospholipids in the Liver of female albino rat: Histochemical Studies. European Journal of Biotechnology and Bioscience, Volume 4, Issue 3, 2016, Pages 60-62
European Journal of Biotechnology and Bioscience