European Journal of Biotechnology and Bioscience

European Journal of Biotechnology and Bioscience


European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 4, Issue 5 (2016)

A review of neonatal jaundice


Biswajit Batabyal

Newborn jaundicernoccurs when a baby has a high level of bilirubin in the blood. Bilirubin is arnyellow substance that the body creates when it replaces old red blood cells.rnThe liver helps break down the substance so it can be removed from the body inrnthe stool. Neonatal jaundice is common, and usually harmless, because ofrnphysiological jaundice or breast-feeding. In some neonates unconjugatedrnbilirubin concentration, coupled with other risk factors, is sufficient tornallow free bilirubin to cross the blood-brain barrier and cause kernicterus.rnAnother subgroup of infants is jaundiced because of elevated conjugatedrnbilirubin; a marker for a number of pathological conditions. Bilirubinrnmeasurement must identify those infants at risk. Transcutaneous bilirubin measurementrnis increasingly used in healthy infants, especially before early discharge orrnat home, to assess the need for laboratory bilirubin measurement.rnTranscutaneous measurements are not covered by laboratory quality assessmentrnschemes. Guidelines on management of neonatal jaundice utilize age in hours andrnother risk factors to define bilirubin action thresholds, which may be as lowrnas 100 μmol/L for sick premature infants, whereas early dischargedrnbabies may only present after bilirubin concentrations are extremely high.rnHence, there is a requirement for accurate total bilirubin measurement fromrn<100 to >500 μmol/L, with sufficient precision to assess the raternof bilirubin change with time. Babies presenting with late jaundice alwaysrnrequire conjugated bilirubin measurement. It is of concern that many total andrndirect bilirubin automated kit methods suffer from haemolysis interference,rnwhile use of in-house methods or modification of commercial methods hasrnvirtually disappeared. External quality assessment has a vital role inrnproviding data on different methods' performance, including accuracy, precisionrnand susceptibility to interference. Laboratories should consider whether theirrnadult bilirubin methods are suitable for neonates
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How to cite this article:
Biswajit Batabyal. A review of neonatal jaundice. European Journal of Biotechnology and Bioscience, Volume 4, Issue 5, 2016, Pages 09-11
European Journal of Biotechnology and Bioscience