Adiponectin acts itsrnanticancer activity by binding to its receptors. Studies have shown thatrnpolymorphisms in the adiponectin receptors are cause in insulin resistance,rntype 2 diabetes, and colon cancer. The aim of this study is to estimate thernprevalence of allele polymorphism of adiponectin receptor 1 rs 2275738 in arnpopulation of india and investigate the role of this polymorphism with increasernrisk of colon cancer.
Methods: The study type is a case - control. 53rnpatients with positive colon cancer as case group and 53 people as controlsrngroup were determined genotyping by using PCR-RFLP.
Results: we observe that the frequencies of CC,CT,TTrngenotypes for ADIPOR1 rs 2275738 was 22/6, 50/9, 26/5 for patients group andrnthe frequencies of CC,CT,TT genotypes for ADIPOR1 rs 2275738 was 32, 39/6, 28/4rnfor control group. The allele frequency of C, T was determined 59/4%, 40/6% forrnpatients group and 47/1%, 52/9% for controls. Allele frequency in the twornpopulations showed significant differences between patients and controls groupsrn(The odds ratio = 1.49, CI 95% = 1.09- 2/33, P = 0.01). The significantrnassociation was observed between adiponectin receptor polymorphisms andrnincreased risk of colon cancer.
Conclusion: The results of this study indicate that the polymorphisms in thernADIPOR1 could be a risk factor for colon cancer.