European Journal of Biotechnology and Bioscience

European Journal of Biotechnology and Bioscience


European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 4, Issue 5 (2016)

Association of Adipor1 SNP Rs 2275738 and risk of colon cancer


Majid Khandouzi, Leila Haghshenas, Manab Deka, Elbert Khiangte, Morteza Kordafshari

Adiponectin acts itsrnanticancer activity by binding to its receptors. Studies have shown thatrnpolymorphisms in the adiponectin receptors are cause in insulin resistance,rntype 2 diabetes, and colon cancer. The aim of this study is to estimate thernprevalence of allele polymorphism of adiponectin receptor 1 rs 2275738 in arnpopulation of india and investigate the role of this polymorphism with increasernrisk of colon cancer.
Methods: The study type is a case - control. 53rnpatients with positive colon cancer as case group and 53 people as controlsrngroup were determined genotyping by using PCR-RFLP.
Results: we observe that the frequencies of CC,CT,TTrngenotypes for ADIPOR1 rs 2275738 was 22/6, 50/9, 26/5 for patients group andrnthe frequencies of CC,CT,TT genotypes for ADIPOR1 rs 2275738 was 32, 39/6, 28/4rnfor control group. The allele frequency of C, T was determined 59/4%, 40/6% forrnpatients group and 47/1%, 52/9% for controls. Allele frequency in the twornpopulations showed significant differences between patients and controls groupsrn(The odds ratio = 1.49, CI 95% = 1.09- 2/33, P = 0.01). The significantrnassociation was observed between adiponectin receptor polymorphisms andrnincreased risk of colon cancer.
Conclusion: The results of this study indicate that the polymorphisms in thernADIPOR1 could be a risk factor for colon cancer.

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How to cite this article:
Majid Khandouzi, Leila Haghshenas, Manab Deka, Elbert Khiangte, Morteza Kordafshari. Association of Adipor1 SNP Rs 2275738 and risk of colon cancer. European Journal of Biotechnology and Bioscience, Volume 4, Issue 5, 2016, Pages 14-16
European Journal of Biotechnology and Bioscience