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Endosulfan andrncyhalothrin are the most commonly used pesticides in the Indian agriculturalrnfields which affect the every biota on the earth directly or indirectly. Therntoxic effect of both pesticides, Endosulfan and cyhalothrin on serumrnelectrolyte profile of fish Rasbora daniconius is evaluated in thernpresent study. The sodium and potassium content decreases as the concentrationrnof toxicants increases. It may be due to stress induced loss of ions due tornincreased excretion via excretory organs.