European Journal of Biotechnology and Bioscience

European Journal of Biotechnology and Bioscience


European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 4, Issue 8 (2016)

Comparative analysis of dipterans mitochondrial genome


Monika Miglani, Surendra K Gakhar

Mitochondrial DNA has a simple structure, it is maternally inherited, with no recombination, and it replicates independently from the nuclear genome. In addition, it has different rate of evolution, usually much faster than that of its nuclear counterpart, facilitating our ability to infer phylogenetic relationships among closely related organisms. The complete mitochondrial genomic sequences belonging to 71 species of order diptera of Class Insecta have been retrieved from the GenBank and Vector base to prepare a database. The base compositional analysis of complete genome, protein coding genes as well as AT rich region suggests that mitochondrial genome is heavily AT biased which may targets mitochondrial genome towards lesser stability and more prone towards directional mutation pressure. Thus, indicating that the higher AT content shows that mitochondrial genome has higher rate of evolution. However, coding content conservation, maternal inheritance, high mutation rate makes the mitochondrial DNA the molecule of choice of evolutionary studies.
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How to cite this article:
Monika Miglani, Surendra K Gakhar. Comparative analysis of dipterans mitochondrial genome. European Journal of Biotechnology and Bioscience, Volume 4, Issue 8, 2016, Pages 54-66
European Journal of Biotechnology and Bioscience