Objective: To determine presence of H. pylori tipA gene in gastric biopsies and risk factors associated with presence of this gene in Abidjan (Côte d'Ivoire). Material and methods: This study included 169 adult patients justifying upper endoscopy at Hospital and University Center of Cocody (Abidjan) for the period from August 2015 to January 2016. Rapid urea test was performed and tipA gene was detected by PCR. Clinical and socio-demographic information was collected from a plug investigation. Results: Rapid urea test was positive at 58% (98/169). TipA gene was detected 58.2% (57/98). Patients with tipA gene had a female predominance of 34/57 (59.7%). Majority of the tipA gene was identified in patients aged 31-40 years (31.6%). Senior staff accounted for 18/57 (31.6%) of holders tipA gene and epigastralgias were the first indication for endoscopy, 35/57 (61.4%). More than half of patients with tipA gene (59.6%) reported having a family history of ulcer syndrome. TipA gene was observed mostly in cases of erythematous gastropathy (56.1%) and pangastropathy (24.6%). Conclusion: high presence of tipA gene in gastric biopsies and risk factors described could contribute to characterization of H. pylori infection in Abidjan.