Vasorelaxant effect of Excoecaria grahamii Stapf leaves aqueous extract on rat isolated thoracic aorta
Anankpètinan Prosper Dabiré, Youssoufou Ouédraogo, Raymond Gourounga Belemtougri, Stanislas Sawadogo
The effects of Excoecaria grahamii aqueous extract (EGAE) on blood pressure and vascular smooth muscle were investigated. EGAE, 0.1 and 20 mg/kg bw, quickly reduced blood pressure in dose-dependent manner. This effect was inhibited by different doses (0.01to 100 μg/kg bw) of atropine. EGAE reduced the effect of adrenaline, phenylephrine and KCl on blood pressure increase and aorta rings contraction. In the presence of L-NAME, the vasorelaxation obtained on the intact thoracic aorta is comparable to that obtained in endothelium absence. Our finding showed that the EGAE has hypotensive and antihypertensive actions on normotensive rats, preventive and curative vasorelexation on thoracic aorta ring precontracted with adrenaline, phenylephrine and KCl via muscarinic and adrenergic receptors. Implication of voltage dependent calcium channels was also discussed.