European Journal of Biotechnology and Bioscience

European Journal of Biotechnology and Bioscience


European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 6, Issue 1 (2018)

Phytochemical and acute toxicity study of Cajanus cajan fabaceae


Zokoré Zazou Ange Kévin, Yapo Adou Francis, Okpekon Aboua Timothée, Miezan Bilé Aka Patrice, Droucoula Guillaume Cyril, Koua Kadio Brou Donald, Kouakou Siransy Gisèle

Cajanus cajan, a plant of the Fabaceae family, is used in food and traditional medicine to treat various diseases. However, there is little information on its chemical composition and the toxicity of its leaves. Thus this study was undertaken to identify the chemical groups of Cajanus cajan leaves which justify its use in traditional medicine and to determine the toxicological parameters. Standard methods of characterization and thin layer chromatography (TLC) were used for phytochemical screening. The acute toxicity study of Cajanus cajan was carried out according to guideline OECD 423 using Wistar female rats. Phytochemical screening indicated the presence of flavonoids, sterols and polyterpenes, polyphenols, catechin tannins, quinone substances and saponosides. The acute toxicity study of the extracts, managed by oral way at Wistar rats, was used to determine 50 % lethal dose (LD50) values of aqueous (LD50 = 3715.35 mg/kg body weight) and hydroethanolic extracts. (LD50 = 1174.90 mg/kg body weight). Also the maximum tolerated dose (MTD) values were 2500 mg/kg and 400 mg/kg body weight respectively for the aqueous and hydroethanolic extracts. The presence of these secondary metabolites would justify the many pharmacological properties of Cajanus cajan. Also, the toxicological data allow to conclude that the aqueous and hydroethanolic extracts are slightly toxic.
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How to cite this article:
Zokoré Zazou Ange Kévin, Yapo Adou Francis, Okpekon Aboua Timothée, Miezan Bilé Aka Patrice, Droucoula Guillaume Cyril, Koua Kadio Brou Donald, Kouakou Siransy Gisèle. Phytochemical and acute toxicity study of Cajanus cajan fabaceae. European Journal of Biotechnology and Bioscience, Volume 6, Issue 1, 2018, Pages 01-05
European Journal of Biotechnology and Bioscience