European Journal of Biotechnology and Bioscience

Authors
Valery M Dembitsky, Tatyana A Gloriozova

Abstract
The present review describes the biological activities of carbon-bridged steroids. More than fifty biologically active compounds have shown confirmed antiviral, anti-tumour, antibacterial, and other activities. The structures and reported and predicted activities of synthetic carbon-bridged steroids are available. With the computer programme PASS and based on structure–activity relationships (SAR), some additional activities are also predicted, which point towards new possible applications of these lipids. This review emphasizes the role of carbon-bridged steroids as an important source and potential leads for drug discovery and they are of great interest to chemists, physicians, biologists, pharmacologists and the pharmaceutical industry.