Cervical cancer is the most common cause of cancer mortality in women worldwide. Human papillomavirus (HPV) identified as the necessary cause of cervical cancer. HPV testing is widely incorporated into cervical cancer screening strategies in western countries. Current screening requires pelvic examination for cervical sampling, which may compromise target population participation due to the fear of the invasive procedures. The acceptance could be raised by introducing non invasive procedures during screening as much as possible. We explored the interchangeability of cervical brush samples and colposcopy directed biopsies for HPV DNA testing, by means of a prospective study conducted in screening populations who tested positive for abnormal cellular change in Pap smear earlier and called for colposcopy for further clinical detection of malignancy and recorded as low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL) cases.
Priya Arumugam, Syed Habeebullah, Subhash Chandra Parija. Biopsy vs Brushing: Comparison of two sampling methods for the detection of HPV-DNA in low grade and high grade squamous intraepithelial lesion cases in colposcopy screening. European Journal of Biotechnology and Bioscience, Volume 6, Issue 1, 2018, Pages 53-55