European Journal of Biotechnology and Bioscience

European Journal of Biotechnology and Bioscience


European Journal of Biotechnology and Bioscience
European Journal of Biotechnology and Bioscience
Vol. 7, Issue 6 (2019)

Molecular docking and green synthesis of silver nanoparticles using Aegle marmelos and it’s anti-bacterial activity


Subasri S, Abilasha S, Poovizhi A, Gilbert Ross Rex K, Prabhu N

Aegle marmelos is a popular medicinal plant in the Ayurveda and Siddha system of medicine. The study is focused on the synthesis of silver nanoparticles with dried and fresh leaves extract of Aegle marmelos by using silver nitrate. The formation of AgNPs of Aegle marmelos is better reducing as well as capping agent and this was studied by UV-VIS spectrophotometer in the range of 480 nm. Then the anti-bacterial activity of 1mM AgNPs of (1ml – 5ml) dried leaves extracts of Aegle marmelos was tested against pathogenic bacteria (E.coli, P. aeruginosa, S.typhi, S.aureus)showed zone of inhibition. Finally, Molecular docking was performed as the bioactive compounds of Aegle marmelos as ligands against the protein target EGFR receptor using Ligand fit of Discover studio software. From this, the best bioactive compound Aegelin was selected by analyzing the Libdock score, absolute energy, amino acid interaction and number of hydrogen bonds. Based on the result obtained it is said that the leaves of Aegle marmelos effectively produced the silver nanoparticles and it exhibits the antibacterial activity and also the active compounds of leaves were inhibits perfectly the EGFR receptor.
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How to cite this article:
Subasri S, Abilasha S, Poovizhi A, Gilbert Ross Rex K, Prabhu N. Molecular docking and green synthesis of silver nanoparticles using Aegle marmelos and it’s anti-bacterial activity. European Journal of Biotechnology and Bioscience, Volume 7, Issue 6, 2019, Pages 01-09
European Journal of Biotechnology and Bioscience