European Journal of Biotechnology and Bioscience

Authors
Rina Kumari, Dharmshila Kumari

Abstract
The present research was designed to evaluate the possible protective potentials of Nyctanthes arbortristis at two different concentrations against the profenofos induced genotoxicity in Swiss albino mice. Profenofos when administered 2mg/ml orally to Swiss albino mice for 30 days increased the frequency of abnormality compare to control in mitotic chromosome. When mice fed only with Nyctanthes arbortristis leaf extract, the abnormality was all most equal to the control group. However, when profenofos with Nyctanthes arbortristis leaf extract fed concurrently, the abnormality was minimized comparison to profenofos treated group at both concentrations of Nyctanthes arbortristis leaf extract, but higher concentration of leaf extract was significantly minimized the genotoxicity comparison to lower concentration of leaf extract. Therefore, it is suggested that leaf extract may reduce the risk of profenofos induced genotoxicity in mice.