Urinary tract infection (UTI) is one of the choice of antibiotics for the treatment of UTI an urgent need to discover new effective treatment solutions. Fosfomycin may be an interesting alternative to the currently used treatments of UTIs. The study was conducted over 6 months perMicrobiology, Chhattisgarh Institute of Medical Science, Bilaspur. A total of 1240 done as per standard microbiological procedures. Methicillin‑resistant Staphylococcus aureus (MRSA), high-aminoglycoside resistance (HLAR), extended spectrum (MBL) production was detected. Culture was positive in 339 (27.4%) cases. Gramproduction was detected in 154 (37.1%) while 82 (21 bacteria, 68 (51.5%) were MRSA. Fosfomycin was effective to fosfomycin in AmpC producers was extremely high effective as only three isolates were sensitive to cotrimoxazole. Pseudomonas species showed 65% and 75% susceptiblee. Fosfomycin has emerged as a promising option,pathogens in which previous antibiotics have failed to cure the infection.